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KMID : 0380020080230010065
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 1 p.65 ~ p.69
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Characteristics of the Antibacterial Substance Produced by Paenibacillus polymyxa JB115
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Jung Hee-Kyoung
Park Seung-Chun
Park Byung-Kwon
Kim Sang-Dal
Nam Doo-Hyun
Hong Joo-Heon
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Abstract
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The culture broth of a -glucan-producing bacterium, Paenibacillus polymyxa JB115, was confirmed to show the antibiosis against pathogenic bacteria of livestock disease. The antibacterial substance produced by P. polymyxa JB115 exhibited strong bactericidal or bacteriostatic effect on the growth of livestock pathogenic bacteria including Staphylococcus aureus, Salmonella choleraesuis, Escherichia coli and Pseudomonas aeruginosa. This antibacterial substance also showed high stabilities in broad pH range (pH 3-11) and in broad temperature range , which is good enough to apply spray-dry method for the formulation of culture broth. It was also found that the antibacterial substance was very stable in artificial gastric fluid and bile acid, which implies the anticipated antibacterial activity against gastrointestinal bacteria harmful for livestocks. In conclusion, the culture broth of P. polymyxa JB115 can be developed as a multifuctional feed additive containing immune-enhancing -glucan as well as antibacterial agent against livestock pathogenic bacteria.
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KEYWORD
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Antibacterial agent, feed additive, Paenibacillus polymyxa, -glucan
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